Longitudinal kinetics of neutralizing antibodies against circulating SARS-CoV-2 variants and estimated level of group immunity of booster-vaccinated individuals during omicron-dominated COVID-19 outbreaks in the Republic of Korea, 2022
Longitudinal kinetics of neutralizing antibodies against circulating SARS-CoV-2 variants and estimated level of group immunity of booster-vaccinated individuals during omicron-dominated COVID-19 outbreaks in the Republic of Korea, 2022
Blog Article
ABSTRACT The coronavirus disease 2019 pandemic persisted for 3 years and is now transitioning to endemicity.We illustrated the change in group immunity induced by vaccination (monovalent vaccines) and breakthrough infections (BIs) in a healthcare worker (HCW) cohort.Five sampling points were analyzed: before the third dose and 1, 3, 5, and 8 months after the vaccination.
The last two points corresponded roughly to 1 and 4 months after omicron BA.1/BA.2 BI.
A semi-quantitative anti-spike binding antibody (Sab) assay and plaque reduction neutralization test (PRNT) against circulating variants were conducted.A linear regression model was utilized to deduce correlation equations.Baseline characteristics and antibody titers after C the third dose were not different between 106 HCWs with or without BI (54/52).
One month after the third dose, BA.1 PRNT increased with wild-type (WT), but 3 months after the third dose, it decreased more rapidly than WT PRNT.After BI, BA.
1 PRNT increased robustly and waned slower than WT.A linear equation of waning kinetics was deduced between log10Sab and months, and the slope became gradual after BI.The estimated BA.
5 PRNT titers at the beginning of the BA.5 outbreak were significantly higher than the BA.1 PRNT titers of the initial BA.
1/BA.2 wave, which might be associated with the smaller size of the BA.5 wave.
BA.1/BA.2 BI after the third dose elicited robust and broad neutralizing activity, preferentially maintaining cross-neutralizing longevity against BA.
1 and BA.5.The estimated kinetics provide an overview of group immunity through the third vaccination and BA.
1/BA.2 BI, correlating with the actual outbreaks.IMPORTANCE This study analyzed changes in group immunity induced by coronavirus disease 2019 (COVID-19) vaccination and BA.
1/BA.2 breakthrough infections (BIs) in a healthcare worker cohort.We investigated the longitudinal Hair Treatment kinetics of neutralizing antibodies against circulating variants and confirmed that BA.
1/BA.2 BIs enhance the magnitude and durability of cross-neutralization against BA.1 and BA.
5.Correlation equations between semi-quantitative anti-spike antibody and plaque reduction neutralization test titers were deduced from the measured values using a linear regression model.Based on the equations, group immunity was estimated to last up to 11 months following the third dose of the COVID-19 vaccine.
The estimated group immunity suggests that the augmented immunity and flattened waning slope through BI could correlate with the overall outbreak size.Our findings could provide a better understanding to establish public health strategies against future endemicity.